Biological activities of extract from Coleonema album in vitro was written by Rarova, L.;Jager, A. K.;Xuehong, G.;Bauer, R.;Gruz, J.;Van Staden, J.;Strnad, M.. And the article was included in South African Journal of Botany in 2019.Name: (2E,4E)-N-Isobutyldeca-2,4-dienamide The following contents are mentioned in the article:
Coleonema album is a South African shrub which is used as an anti-inflammatory. A methanolic leaf extract of C. album was here tested in vitro in various anti-inflammatory assays to establish a possible mode of action, as well as for cytotoxicity. The C. album extract did not change the signaling of anti-inflammatory activity in vitro. The extract inhibited COX-1, COX-2 and IL-6, but not ELAM or ICAM-1. Pellitorine, an alkamide isolated and identified from C. album, did not show any activity in the anti-inflammatory assays. The extract showed no cytotoxicity in normal and cancer cell lines. Finally, pellitorine was identified in C. album by UHPLC-QTOF-MS and its concentration was determined by an external standard method. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Name: (2E,4E)-N-Isobutyldeca-2,4-dienamide).
(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Name: (2E,4E)-N-Isobutyldeca-2,4-dienamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics