Paulsen, Marianne H. published the artcileAn amphipathic cyclic tetrapeptide scaffold containing halogenated β2,2-amino acids with activity against multiresistant bacteria, Product Details of C11H22N2O4, the publication is Journal of Peptide Science (2018), 24(10), n/a, database is CAplus and MEDLINE.
The present study describes the synthesis and biol. studies of a small series of head-to-tail cyclic tetrapeptides of the general structure c(Lys-β2,2-Xaa-Lys) containing one lipophilic β2,2-amino acid and Lys, Gly, Ala, or Phe as the Xaa residue in the sequence. The peptides were investigated for antimicrobial activity against gram-pos. and gram-neg. reference strains and 30 multiresistant clin. isolates including strains with extended spectrum β-lactamase-carbapenemase (ESBL-CARBA) production Toxicity was determined against human red blood cells. The most potent peptides showed high activity against the gram-pos. clin. isolates with min. inhibitory concentrations of 4-8 μg/mL and low hemolytic activity. The combination of high antimicrobial activity and low toxicity shows that these cyclic tetrapeptides containing lipophilic β2,2-amino acids form a valuable scaffold for designing novel antimicrobial agents.
Journal of Peptide Science published new progress about 2418-95-3. 2418-95-3 belongs to amides-buliding-blocks, auxiliary class Chiral,Carboxylic acid,Amine,Aliphatic hydrocarbon chain,Ester,Amino acide derivatives, name is H-Lys(Boc)-OH, and the molecular formula is C11H22N2O4, Product Details of C11H22N2O4.
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