Quantitative structure activity relationship of the aromatic carboxylic acid derivatives was written by Xue, Feiqun;Wang, Hanqing;Zhao, Rongcai. And the article was included in Zhongguo Shouyi Xuebao in 1996.Synthetic Route of C11H15NO2 This article mentions the following:
The repellency and QSAR of forty aromatic carboxylic acid derivatives were analyzed using Hansch’s method in the study. The results indicated that the repellency of a series of the compounds is significantly correlated with the boiling coefficient The size of substituent of the compounds should not be larger than benzene, the most appropriate value of the partition coefficient (logP) is about 3.50. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Synthetic Route of C11H15NO2).
N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Synthetic Route of C11H15NO2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics