Enamines as Surrogates of Alkyl Carbanions for the Direct Conversion of Secondary Amides to α-Branched Ketones was written by Liu, Yong-Peng;Wang, Shu-Ren;Chen, Ting-Ting;Yu, Cun-Cun;Wang, Ai-E.;Huang, Pei-Qiang. And the article was included in Advanced Synthesis & Catalysis in 2019.Related Products of 13255-50-0 This article mentions the following:
A direct transformation of secondary amides into α-branched ketones with enamines as soft alkylation reagents was developed. In this reaction, enamines serve as surrogates of alkyl carbanions, rather than the conventional enolates equivalent in the Stork’s reactions, which allowed for the easy introduction of alkyl groups with electrophilic functional groups. In the presence of 4 Å mol. sieves, the method can be extended to the one-pot coupling of secondary amides with aldehydes to yield ketones. In the experiment, the researchers used many compounds, for example, 4-Formyl-N-isopropylbenzamide (cas: 13255-50-0Related Products of 13255-50-0).
4-Formyl-N-isopropylbenzamide (cas: 13255-50-0) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Related Products of 13255-50-0
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics