Synthesis and antibacterial activity of novel vanillic acid hybrid derivatives was written by Satpute, Maruti S.;Gangan, Vijay D.;Shastri, Indu. And the article was included in Rasayan Journal of Chemistry in 2019.Electric Literature of C13H24N2O This article mentions the following:
Novel ester / hybrid derivatives of vanillic acid were synthesized and tested for potential antibacterial activity. This combinatorial synthesis of novel vanillic ester / hybrid derivatives was useful approach to generate potent chemotherapeutic agents in developing new drug candidates. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Electric Literature of C13H24N2O).
1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Electric Literature of C13H24N2O
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics