An efficient synthesis of Weinreb amides and ketones via palladium nanoparticles on ZIF-8 catalysed carbonylative coupling was written by Thanh Dang, Tuan;Chen, Anqi;Majeed Seayad, Abdul. And the article was included in RSC Advances in 2014.Synthetic Route of C9H10BrNO2 This article mentions the following:
The heterogeneously catalyzed carbonylative coupling reactions such as aminocarbonylation and Suzuki-carbonylation are reported using Pd nanoparticles supported on ZIF-8 for efficient and environmentally attractive synthesis of Weinreb amides ArC(O)N(CH3)OCH3 [Ar = 4-CH3C6H4, 3,4,5-(OCH3)3C6H2, pyridin-3-yl, pyrimidin-5-yl, etc.] and ketones from aryl bromides ArBr or iodides ArI. The catalyst is air stable, offers high activity with very low palladium leaching and is recyclable. The presence of a phosphine ligand was required when ArBr were used as substrates, while no ligand was necessary when ArI were used. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2Synthetic Route of C9H10BrNO2).
4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Synthetic Route of C9H10BrNO2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics