Design, synthesis, and anticancer activities of 8,9-substituted Luotonin A analogs as novel topoisomerase I inhibitors was written by Xiang, Yuanhang;Li, Haiping;Wang, Jun;Peng, Xiaozhi;Hu, Chunling;Luo, Laichun. And the article was included in Medicinal Chemistry Research in 2021.Reference of 119023-25-5 This article mentions the following:
A series of 8,9-substituted Luotonin A analogs were designed, synthesized, and evaluated for antiproliferative activity against four cancer cell lines. The structure-activity relationship study revealed that the in vitro anticancer activity of Luotonin A was significantly improved by the introduction of 8-piperazine group and the 5-deaza modification. Two promising compounds 6a and 7a displayed potent topoisomerase I inhibitory activity. And a rational binding mode of 7a with topoisomerase I-DNA complex was proposed based on the mol. docking study. In the experiment, the researchers used many compounds, for example, 2-Amino-4-fluorobenzamide (cas: 119023-25-5Reference of 119023-25-5).
2-Amino-4-fluorobenzamide (cas: 119023-25-5) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Reference of 119023-25-5
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics