Zhao, Meng Meng et al. published their research in Science China: Chemistry in 2013 | CAS: 106675-70-1

N1,N2-Dimethoxy-N1,N2-dimethyloxalamide (cas: 106675-70-1) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Synthetic Route of C6H12N2O4

Ru-catalyzed highly enantioselective hydrogenation of α-keto Weinreb amides was written by Zhao, Meng Meng;Li, Wan Fang;Ma, Xin;Fan, Wei Zheng;Tao, Xiao Ming;Li, Xiao Ming;Xie, Xiao Min;Zhang, Zhao Guo. And the article was included in Science China: Chemistry in 2013.Synthetic Route of C6H12N2O4 This article mentions the following:

Asym. hydrogenation of α-keto Weinreb amides was realized with [Ru((S)-Sunphos)(benzene)Cl]Cl as the catalyst and CeCl3·7H2O as reagent. A series of enantiopure α-hydroxy Weinreb amides (up to 97% ee) have been obtained. A catalytic amount of CeCl3·7H2O is essential for the high reactivity and enantioselectivity and the ratio of CeCl3·7H2O to [Ru((S)-Sunphos)(benzene)Cl]Cl plays an important role in the hydrogenation reaction. The synthesis of the target compounds was achieved using (η6-benzene)chloro[1,1′-[(4S)-2,2,2′,2′-tetramethyl[4,4′-bi-1,3-benzodioxole]-5,5′-diyl]bis[1,1-diphenylphosphine-κP]]ruthenium chloride (1:1) as efficient catalyst. Starting materials thus used included N-Methoxy-N-methyl-α-oxobenzeneacetamide, N-methoxy-N-methyl-α-oxo-2-thiopheneacetamide (thiophene Weinreb oxo amide), N-methoxy-N-methyl-2-oxopropanamide, N-methoxy-N-methyl-α-oxobenzenepropanamide. The title compounds thus formed included (+)-α-hydroxy-N-methoxy-N-methylbenzeneacetamide, (αR)-α-hydroxy-N-methoxy-N-methylbenzenepropanamide, etc. In the experiment, the researchers used many compounds, for example, N1,N2-Dimethoxy-N1,N2-dimethyloxalamide (cas: 106675-70-1Synthetic Route of C6H12N2O4).

N1,N2-Dimethoxy-N1,N2-dimethyloxalamide (cas: 106675-70-1) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Synthetic Route of C6H12N2O4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics