Metabolism of procarbazine (N-isopropyl-α-(2-methylhydrazino)-p-toluamide hydrochloride) was written by Prough, R. A.;Coomes, M. W.;Cummings, S. W.;Wiebkin, P.. And the article was included in Advances in Experimental Medicine and Biology in 1982.Application In Synthesis of 4-Formyl-N-isopropylbenzamide This article mentions the following:
The liver microsomal metabolism of procarbazine (I) [366-70-1] was studied in various liver microsomal preparations from rats. A scheme is suggested for I metabolism in which the intermediate azoprocarbazine [2235-59-8] is transformed by independent pathways to methylating agents via 2 azoxy derivatives or to CH4 [74-82-8] via some other reactive intermediate. In the experiment, the researchers used many compounds, for example, 4-Formyl-N-isopropylbenzamide (cas: 13255-50-0Application In Synthesis of 4-Formyl-N-isopropylbenzamide).
4-Formyl-N-isopropylbenzamide (cas: 13255-50-0) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Application In Synthesis of 4-Formyl-N-isopropylbenzamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics