Drost, R. H. et al. published their research in Pharmaceutisch Weekblad in 1967 | CAS: 19311-91-2

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Quality Control of N,N-Diethylsalicylamide

Identification of toxic substances by means of Feldstein’s extraction method, thin-layer chromatography, and uv spectrometry. I. Basic substances was written by Drost, R. H.;Reith, Jan F.. And the article was included in Pharmaceutisch Weekblad in 1967.Quality Control of N,N-Diethylsalicylamide This article mentions the following:

Biol. material was extracted with 1,2-dichloroethane, according to Feldstein, and separated into strongly acid, weakly acid, neutral, basic, and basic substances with a phenol group. The basic substances were separated by thin-layer chromatog. on activated kieselgel G with CHCl3-Et2NH (90:10), CHCl3-Me2CO-Et2NH (50:40:10), CHCl3-cyclohexane-Et2NH (40:50:10), cyclohexane-Et2NH (90:10), and C6H6-EtOAc-Et2NH (70:20:10). The spots were located with uv light and the compounds identified by their reaction with a platinic chloride-KI spray and by the uv spectrum of a dichloroethane extract The Rf values, color reactions, and spectral data are given for 32 substances. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Quality Control of N,N-Diethylsalicylamide).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Quality Control of N,N-Diethylsalicylamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics