Design, synthesis, and structure-activity relationship of new isobenzofuranone ligands of protein kinase C was written by Baba, Yoshiyasu;Ogoshi, Yosuke;Hirai, Go;Yanagisawa, Takeshi;Nagamatsu, Kumiko;Mayumi, Satoshi;Hashimoto, Yuichi;Sodeoka, Mikiko. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2004.COA of Formula: C11H15NO2 This article mentions the following:
Protein kinase C (PKC) is a family of enzymes, which play important roles in intracellular signal transduction. PKC ligands having an isobenzofuranone template, based on the proposed interaction of DAG (1,2-diacyl-sn-glycerol) with the PKCδ C1B ligand-binding domain were designed. Several isobenzofuranone derivatives were synthesized and their PKCα binding activities were evaluated. (-)-2,2-Dimethylpropanoic acid [(1R)-4-(dodecyloxy)-1,3-dihydro-1-(hydroxymethyl)-3-oxo-1-isobenzofuranyl]methyl ester (I) was found to be a strong PKCα ligand, and the structure-activity relationship is well explained by our proposed binding model. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2COA of Formula: C11H15NO2).
N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.COA of Formula: C11H15NO2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics