Formation of the Tertiary Sulfonamide C(sp3)-N Bond Using Alkyl Boronic Ester via Intramolecular and Intermolecular Copper-Catalyzed Oxidative Cross-Coupling was written by Kim, Dong Sun;Lee, Hong Geun. And the article was included in Journal of Organic Chemistry in 2021.Synthetic Route of C9H13NO2S This article mentions the following:
A synthetic strategy for the formation of C(sp3)-N bonds, particularly through a Cu-catalyzed oxidative cross-coupling, is rare. Herein, the authors report a novel synthetic approach for the preparation of tertiary sulfonamides via Cu-catalyzed intra- and intermol. oxidative C(sp3)-N cross-coupling reactions. This method allows the use of the readily available C(sp3)-based pinacol boronate as a substrate and the tolerance of a wide range of functional groups under mild reaction conditions. The success of this strategy relies on the unprecedented additive effects of silanol and NaIO4. In the experiment, the researchers used many compounds, for example, N-Isopropylbenzenesulfonamide (cas: 5339-69-5Synthetic Route of C9H13NO2S).
N-Isopropylbenzenesulfonamide (cas: 5339-69-5) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Synthetic Route of C9H13NO2S
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics