Dealkoxylation of N-alkoxyamides without an external reductant driven by Pd/Al cooperative catalysis was written by Suzuki, Hirotsugu;Shiomi, Takahiro;Yoneoka, Kenji;Matsuda, Takanori. And the article was included in Organic & Biomolecular Chemistry in 2020.Computed Properties of C10H10F3NO2 This article mentions the following:
Lewis acid-assisted palladium-catalyzed dealkoxylation of N-alkoxyamides has been developed. This reaction proceeded smoothly with a range of N-alkoxyamides in the absence of an external reductant, thereby establishing a convenient and reductant-free protocol. In addition, a gram-scale reaction could be achieved. Preliminary mechanistic investigations indicated that β-hydrogen elimination from a palladium alkoxide intermediate generated an intramol. hydride source. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7Computed Properties of C10H10F3NO2).
N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Computed Properties of C10H10F3NO2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics