Molecular features of sulfonamide transport in renal excretory processes was written by Despopoulos, Agamemnon;Callahan, Paul X.. And the article was included in American Journal of Physiology in 1962.Computed Properties of C7H10N2O2S This article mentions the following:
Renal tubular excretory transport of selected sulfonamides is assumed to require a physicochem. interaction between the substrate and a postulated intracellular receptor mol. It is proposed that substrate specificity in this transport system depends on the presence of the intramolecular sequence, SO2N–, in the sulfonamide. Reactivity of this group requires ionization at N, localization of the net neg. charge at N, and electronegativity at each O sufficient for the formation of H bonds. Presence of these 3 features in favorable combination permits transport. These proposals are supported by analysis of the physicochem., biochem., and physiol. behavior of 52 sulfonamides both in surviving rabbit renal cortical slices and in intact mongrel dogs. Although transport of sulfonamides is treated as an independent biochem. mechanism, its relation to the renal hippurate transport system is recognized and similar responses of both classes of substrates to probenecid or to acetate are demonstrated exptl. In the experiment, the researchers used many compounds, for example, 4-Amino-3-methylbenzenesulfonamide (cas: 53297-70-4Computed Properties of C7H10N2O2S).
4-Amino-3-methylbenzenesulfonamide (cas: 53297-70-4) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Computed Properties of C7H10N2O2S
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics