N-(2-(1H-indol-3-yl)ethyl)-2-(2-fluoro-[1,1”-biphenyl]-4-yl)propanamide was written by Manolov, Stanimir;Ivanov, Iliyan;Bojilov, And Dimitar. And the article was included in Molbank in 2021.Electric Literature of C13H24N2O This article mentions the following:
N-(2-(1H-Indol-3-yl)ethyl)-2-(2-fluoro-[1,1”-biphenyl]-4-yl)propanamide were prepared by a reaction between tryptamine and flurbiprofen, applying N,N”-dicyclohexylcarbodiimide, as a coupling agent. The obtained new amide has a fragment similar to Brequinar, a compound used in SARS-CoV-2 treatment trials. The newly synthesized compound was fully analyzed and characterized via 1H, 13C-NMR, UV, IR, and mass spectral data. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Electric Literature of C13H24N2O).
1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Electric Literature of C13H24N2O
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics