Synthesis and mass spectrometry of some a-dialkylaminoalkylphenols structurally related to certain antiparasitic agents was written by El-Mouafi, Hamdi M. R.. And the article was included in Egyptian Journal of Pharmaceutical Sciences in 1991.Category: amides-buliding-blocks This article mentions the following:
Condensation of aminohydroxybenzenemethanamine derivatives (Mannich bases), e.g. I with 3-chloro-2-(2-pyridyl)-1-indenone gave the [[[(dialkylamino)methyl]hydroxyphenyl]amino](2-pyridyl)indenone II. Mannich reaction of N-(4-hydroxyphenyl)benzenesulfonamide with formaldehyde and diethylamine gave the [[(dialkylamino)methyl]hydroxyphenyl]benzenesulfonamide III. The mass spectrum of III was discussed. The antiparasitic activity of these compounds was not reported. In the experiment, the researchers used many compounds, for example, N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6Category: amides-buliding-blocks).
N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Category: amides-buliding-blocks
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics