Separation and quantitation of possible degradation products of procarbazine hydrochloride in its dosage form was written by Burce, Gary L.;Boehlert, Judy P.. And the article was included in Journal of Pharmaceutical Sciences in 1978.SDS of cas: 13255-50-0 This article mentions the following:
A stability-indicating assay for the degradation products of procarbazine hydrochloride (I) [366-70-1] was developed using high-pressure liquid chromatog. The method uses a buffered MeOH-M2O mobile phase on a reversed-phase column. Concentrations of degradation products as low as 0.04 mg/mL, 0.02% degradation, was quantitated using an internal standard of cinnamyl alc. The typical range for degradation products in procarbazine capsules is 0.1-0.5% after as long as 4.5 yr. In the experiment, the researchers used many compounds, for example, 4-Formyl-N-isopropylbenzamide (cas: 13255-50-0SDS of cas: 13255-50-0).
4-Formyl-N-isopropylbenzamide (cas: 13255-50-0) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.SDS of cas: 13255-50-0
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics