Aza-Knoevenagel-type condensation of secondary amides: direct access to N-monosubstituted β,β-difunctionalized enamines was written by Huang, Pei-Qiang;Ou, Wei;Ye, Jian-Liang. And the article was included in Organic Chemistry Frontiers in 2015.Reference of 13255-50-0 This article mentions the following:
An efficient approach to N-monosubstituted β,β-difunctionalized enamines, a class of versatile building blocks for the synthesis of bioactive compounds, was reported. The method was based on the triflic anhydride-mediated direct aza-Knoevenagel-type condensation of secondary amides with active methylene compounds The reaction showed good chemoselectivity and functional group tolerance. A number of title compounds were synthesized in good to excellent yields in one pot from readily available starting materials. In the experiment, the researchers used many compounds, for example, 4-Formyl-N-isopropylbenzamide (cas: 13255-50-0Reference of 13255-50-0).
4-Formyl-N-isopropylbenzamide (cas: 13255-50-0) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Reference of 13255-50-0
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics