Evaluation of antioxidant, antidiabetic and antihyperlipidaemic activity of methanolic extract of Casearia elliptica in alloxan induced male wistar diabetic rats was written by Tarun, Mudadla;Praveen, Vataka;Ramani, Seemusiri Usha;Devi, Yeddu Iswarya;Madhu, Chandaka. And the article was included in Indo American Journal of Pharmaceutical Sciences in 2022.SDS of cas: 10238-21-8 This article mentions the following:
Background: Diabetes mellitus is a group of metabolic disorders with the common manifestations, hyperglycemia. Alloxan causes a massive reduction in insulin release by the destruction of β cells of the islets of langerhans, there by inducing hyperglycemia. Alloxan has been shown to induce free radical production and cause tissue injury. The aim of the present investigation was to evaluate the antioxidant, antihyperlipidemic and antidiabetic activity of methanolic extract taken from Casearia elliptica. Methods: The methanolic extract of Casearia elliptica whole plant used for the study. The Phytochem. test, acute toxicity study and oral glucose test was performed. Diabetes was induced in rat by single intra-peritoneal injection of alloxan (120 mg/kg). Male albino Wistar rats were divided into five groups each consisting of six animals as follows:Group I- Administered vehicle serves as Normal control.,Group II- Administered Alloxan (120 mg/kg s.c.) serves as diabetic control,Group III- Administered Reference Standard, (Glibenclamide 10 mg/kg, orally once daily),Group IV- Diabetic rats treated with Casearia elliptica (250mg/kg b.wt), serves as treated group,Group V- Diabetic rats treated with Casearia elliptica (500mg/kg b.wt), serves as treated group. Bodyweight of each rat in the different groups was recorded daily. Biochem. and antioxidant enzyme parameters were determined on day 14. Histol. of different organ (heart, liver, kidney, and pancreas) was performed after sacrificing the rats with euthanasia. Results: Preliminary Phytochem. investigation of methanolic extracts of whole plant of Casearia elliptica was carried out and found that it contains fixed oil, saponins, alkaloids and carbohydrates. The maximum tolerated dose of root of Casearia elliptica was found as 2000 mg/kg after completion of toxicity study according to OECD guideline. The methanolic extract of whole plant of Casearia elliptica has potential anti-diabetic action in alloxan induced diabetic rats and the effect was found equally effective with glibenclamide at higher dose. Our study clearly reveals that MECE has some obvious therapeutic implications in treating hyperglycemia, atherogenic lipoprotein profile and also possess antioxidant activity. In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8SDS of cas: 10238-21-8).
5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.SDS of cas: 10238-21-8
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