Synthetic Route of 104060-23-3,Some common heterocyclic compound, 104060-23-3, name is N-Boc-2-(4-Aminophenyl)ethanol, molecular formula is C13H19NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
4-(tert-Butoxycarbonylamino)phenethyl 3-nitro-benzenesulfonate 4.25 g (42 mmole) triethylamine was added to 10 g (42 mmole) 2-[4-(tert-butoxycarbonylamino)phenyl]-1-ethanol dissolved in dichloromethane. The reaction mixture was cooled to -25 C. and 9.34 g (42 mmole) 3-nitrobenzenesulfonyl chloride was added in portions. The reaction mixture was poured on to icewater, the phases were separated and the organic phase was dried (sodium sulfate), filtered and the solvent was evaporated in vacuo. The residue was purified by chromatography on silica gel using dichloromethane as eluent to give 8.3 g (yield 47%) 4-(tert-butoxycarbonylamino)-phenethyl 3-nitro-benzenesulfonate as yellow crystals.
The synthetic route of 104060-23-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AstraZeneca AB; US6288096; (2001); B1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics