Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 24036-52-0, name is 6-Bromo-2H-1,4-benzoxazin-3(4H)-one, A new synthetic method of this compound is introduced below., Product Details of 24036-52-0
To a 25 mL flask was added 6-bromo-2H-benzo[b][1,4]oxazin-3(4H)-one (0.46 g, 2 mmol), P2S5 (0.89 g, 4 mmol) and THF (8 mL), thereaction mixture was heated at 90 C and stirred for 8 h. After the reactionwas completed, the THF was removed at reduced pressure andpour into water, filtered dry and directly reacted with piperazine(0.34 g, 4 mmol) at 90 C in THF without purification. Then the THFwas removed at reduced pressure and the residue was purified on silicagel with chloroform/methanol (V:V 10:1) to give the title compound asa white powder. Yield 56.2%, oil. 1H NMR (400 MHz, DMSO-d6) delta 6.99(d, J=2.4 Hz, 1H, Ar-H), 6.92 (dd, J=8.4, 2.4 Hz, 1H, Ar-H), 6.74 (d,J=8.4 Hz, 1H, Ar-H), 4.76 (s, 2H, Ar-H), 3.50-3.39 (m, 4H, CH2¡Á2),3.19 (m, 4H, CH2¡Á2). ESI-MS: m/z 296.0 [M+H]+.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Dong, Fu-Dan; Liu, Dan-Dan; Deng, Cheng-Long; Qin, Xiao-chun; Chen, Kai; Wang, Jian; Song, Hong-Rui; Ding, Huai-Wei; Bioorganic and Medicinal Chemistry; vol. 26; 14; (2018); p. 3982 – 3991;,
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