In an article, author is Li, Yonghong, once mentioned the application of 71432-55-8, Name is tert-Butyl N,N’-diisopropylcarbamimidate, molecular formula is C11H24N2O, molecular weight is 200.3211, MDL number is MFCD06657672, category is amides-buliding-blocks. Now introduce a scientific discovery about this category, Category: amides-buliding-blocks.
Transition metal-free direct dehydrogenative arylation of activated C(sp(3))-H bonds: synthetic ambit and DFT reactivity predictions
A transition metal-free dehydrogenative method for the direct mono-arylation of a wide range of activated C(sp(3))-H bonds has been developed. This operationally simple and environmentally friendly aerobic arylation uses tert-BuOK as the base and nitroarenes as electrophiles to prepare up to gram quantities of structurally diverse sets (>60 examples) of alpha-arylated esters, amides, nitriles, sulfones and triaryl methanes. DFT calculations provided a predictive model, which states that substrates containing a C(sp(3))-H bond with a sufficiently low pK(a) value should readily undergo arylation. The DFT prediction was confirmed through experimental testing of nearly a dozen substrates containing activated C(sp(3))-H bonds. This arylation method was also used in a one-pot protocol to synthesize over twenty compounds containing all-carbon quaternary centers.
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