Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 56-84-8, Name is H-Asp-OH, SMILES is N[C@@H](CC(O)=O)C(O)=O, in an article , author is Crowe, Molly S., once mentioned of 56-84-8, SDS of cas: 56-84-8.
Topological control of supramolecular crystal structures of phenylene bis-monothiooxamate derivatives and in vitro anticancer activity
This paper describes the synthesis, physical characterization, X-ray crystal structures and antitumoral activity against human carcionogenic cells of three new diethyl ester acid derivatives of phenylene bismonothiooxamate compounds, namely Et2H2opbta (1), Et(2)H(2)mpbta (2) and Et(2)H(2)ppbta (3) [opbta = N,N’-1,2-phenylenebis(2-thiooxamate), mbpta = N,N’-1,3-phenylenebis(2-thiooxamate) and ppbta = N,N’-1,4-phenylenebis(2-thiooxamate)]. Compounds 1-3 were obtained under mild conditions by reaction of the corresponding N,N’-phenylenebis(oxamate) analogues and Lawesson’s reagent resulting in the formation of C=S bonds at the carbonyl amide functions. Crystal structures of 1-3 consist of 1D supramolecular assemblies of centrosymmetric H2Et2ppbta (3) or noncentrosymmetric chiral H(2)Et(2)opbta (1) and H(2)Et(2)mpbta (2) molecules with opposite helical chirality (M and P enantiomers) resulting from intermolecular N H center dot center dot center dot O (1 and 3) or N H center dot center dot center dot S (2) hydrogen bonds between the amide hydrogen atoms and the carbonyl ester oxygen or thionyl amide sulfur atoms from the thiooxamate moieties respectively, together with weak S center dot center dot center dot S bonds between the thionyl amide sulfur atoms (1). The cytotoxicity of H(2)Et(2)xpbta [x = o (1), m (2) and p (3)] against chronic myelogenous leukemia cells was evaluated and the bioactivity follows the order 1 >> 2 > 3, compound 1 being six and ten times more active than 2 and 3, respectively. (C) 2017 Elsevier B.V. All rights reserved.
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