Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 657-27-2, Name is L-Lysine monohydrocholoride, molecular formula is C6H15ClN2O2, belongs to amides-buliding-blocks compound, is a common compound. In a patnet, author is Gagnot, Glwadys, once mentioned the new application about 657-27-2, Formula: C6H15ClN2O2.
The effect of terminal groups and halogenation of KLVFF peptide on its activity as an inhibitor of beta-amyloid aggregation
The aggregation of A beta peptide into amyloid fibrils in the brain is associated with Alzheimer’s disease (AD). Inhibition of A beta aggregation seemed a potential treatment for AD. It was previously shown that a short fragment of A beta peptide (KLVFF, 16-20) bound A beta inhibited its aggregation. In this work, using KLVFF peptide, we synthesized two peptide families and then evaluated their inhibitory capacities by conventional assays such as thioflavin T (ThT) fluorescence spectroscopy, turbidity measurement, and the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS). The effect of peptide terminal groups on its inhibitory activity was first studied. Subsequently, the influence of halogenated amino acids on peptide anti-aggregation properties was investigated. We found that iodinated peptide with amine in the N and amide in the C termini, respectively, was the best inhibitor of A beta fibers formation. Halogenated peptides seemed to decrease the number of A beta fibrils; however, they did not reduce A beta cytotoxicity. The data obtained in this work seemed promising in developing potential peptide drugs for treatment of AD.
We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 657-27-2. The above is the message from the blog manager. Formula: C6H15ClN2O2.