The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. SDS of cas: 3493-12-7, 3493-12-7, Name is DL-Methionine Methylsulfonium Chloride, SMILES is C[S+](CCC(N)C(O)=O)C.[Cl-], in an article , author is Mendelman, Netanel, once mentioned of 3493-12-7.
Alzheimer’s disease (AD) is a neurodegenerative disorder known for the presence of amyloid beta plaques resulting from the sequential action of beta-secretase and gamma-secretase on amyloid precursor protein. We developed and synthesized, through click reactions, a new family of iminochromene carboxamides containing different aminomethylene triazole. The BACE1 inhibition, neuroprotective capacity and metal chelation of these derivatives make them ideal candidates against AD. Most of the synthesized compounds were shown to have potent BACE1 inhibitory activity in a FRET assay, with an IC50 value of 2.2 mu M for the most potent compound. Moreover, molecular modeling evaluation of these BACE1 inhibitors demonstrates the vital role of the amine and amide linkers through hydrogen bond interactions with key amino acids in the BACE1 active site. Our in vitro neuroprotective evaluations in PC12 neuronal cells of All-induced neuroprotection demonstrated promising activity for most of the compounds as neuroprotective agents. Based on our findings, we propose that introduction of a phthalimide substitute on the triazole ring shown to be interesting multifunctional lead compound worthy of further study. (C) 2017 Elsevier Masson SAS. All rights reserved.
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 3493-12-7, you can contact me at any time and look forward to more communication. SDS of cas: 3493-12-7.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics