Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 1492-24-6, Name is H-Abu-OH, molecular formula is C4H9NO2. In an article, author is Shcherbina, L.,once mentioned of 1492-24-6, HPLC of Formula: https://www.ambeed.com/products/1492-24-6.html.
The ability of the 2-substituted aniline motif to serve as a scaffold for designing potential LuxR-regulated quorum sensing (QS) modulators has been investigated, using docking experiments and biological evaluation of a series of 15 specially synthesized compounds. Aniline, 2-acetyl-aniline and 2-nitroaniline were considered, as well as their N-acylated derivatives. Docking experiments showed that the 2-substituted aniline motif fits within the LuxR binding site at the place of the lactone moiety of AHL, and the biological evaluation revealed QS antagonisitic activity for several compounds, validating the hypothesis that this scaffold acts on QS. Structure activity relationships are discussed regarding interactions with the key residues of the LuxR binding site, showing significant variations in the H-bonding pattern.
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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics