Related Products of 138-41-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 138-41-0 name is Carzenide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of (3aS,6aS)-tert-butyl hexahydropyrrolo[3,4-c]pyrrole-2(lH)-carboxylate (intermediate 3; 206 mg, 970 muiotaetaomicron), N-methylmorpholine (294 mg, 2.91 mmol) and 4- sulfamoylbenzoic acid (203 mg, 970 muiotaetaomicron) in N,N-dimethylformamide (10 ml) was added 0-(7- azabenzotriazol-l-yl)-N,N,N’,N’ -tetramethyluronium hexafluoro-phosphate (369 mg, 970 muiotaetaomicron) at 0C, then after 10 min the ice-bath was removed. After 16 h the reaction mixture was partitioned between dichloromethane and sat. aq. sodium hydrogencarbonate solution. The organic layer was washed with sat. aq. ammonium chloride solution and brine, dried over magnesium sulfate, filtered and evaporated. After trituration in tert-butyl methyl ether the precipitate was collected by filtration to afford the title compound (348 mg, 91 ). Light yellow solid, MS: 396.6 (M+H)+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Carzenide, and friends who are interested can also refer to it.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; HERT, Jerome; HUNZIKER, Daniel; MATTEI, Patrizio; MAUSER, Harald; TANG, Guozhi; WANG, Lisha; WO2014/139978; (2014); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics