Electric Literature of 108468-00-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 108468-00-4 as follows.
100 mg (0.109 mmol) of compound 3d was dissolved in 4 ml of DMF and cooled to -15 C. After addition of 36 tl (0.327 mmol) of NMM and 15 tl (0.109 mmol) CKIBE, the solution was stirred for 15 mm, followed by addition of 40mg (0.169 mmol) ofBoc-p-diaminoxylene and 12 tl (0.109 mmol) of NMM. The mixture was stirred for one hour at 0 C. and overnight at RT. The solvent was removed in vacuo, the residue was mixed with 1 ml 90% TFA and stirred for 2 h at RT. After removing the solvent in vacuo, the residue was dissolved in 8 ml of 30% B and purified by prep. HPLC (start at 10% B). Fractions containing the product were combined, the solvent was removed in vacuo and the residue dissolved in 80% t-butanol/water and lyophilized.jOllO] Yield: 39
According to the analysis of related databases, 108468-00-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PHILIPPS-UNIVERSITAeT MARBURG; Steinmetzer, Torsten; Saupe, Sebastian; US2014/213781; (2014); A1;,
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