Related Products of 4141-08-6, The chemical industry reduces the impact on the environment during synthesis 4141-08-6, name is 2-Amino-N-methylbenzamide, I believe this compound will play a more active role in future production and life.
To a suspension of A-2 (50 mg, 0.19 mmol) in 3 ml AcOEt (3 ml) at rt under an argon atmosphere were added 2-amino-N-methylbenzamide (29 mg, 0.19 mmol) and N-ethyl-diisopropylamine (0.1 ml, 0.59 mmol). The yellow suspension was cooled to 0 C. and propyl-phosphonic anhydride (50% in AcOEt, 0.31 ml, 0.48 mmol) was added. The suspension was stirred at 0 for 30 min and at rt overnight. The solvent was evaporated. The crude product was purified by silica gel chromatography using a CH2Cl2/MeOH gradient to provide the title compound (46 mg, 61%) as yellow solid.MS: M=389.2 (M+H)+
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Amino-N-methylbenzamide, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Bleicher, Konrad; Flohr, Alexander; Groebke Zbinden, Katrin; Gruber, Felix; Koerner, Matthias; Kuhn, Bernd; Peters, Jens-Uwe; Sarmiento, Rosa Maria Rodriguez; US2011/306589; (2011); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics