Recently I am researching about RATIONAL DESIGN; COMPLEXATION; ZR-89; DESFERRIOXAMINE; ZIRCONIUM-89, Saw an article supported by the U.S. National Science FoundationNational Science Foundation (NSF) [CHE-1610755]; NSFNational Science Foundation (NSF) [DGE 0965983]; National Cancer Institute at the National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Cancer Institute (NCI) [R21 CA201999]; National Institutes of Health Cancer Center Support GrantUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USA [P30 CA08748]; NATIONAL CANCER INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Cancer Institute (NCI) [R21CA201999, P30CA008748] Funding Source: NIH RePORTER; NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Center for Advancing Translational Sciences (NCATS) [UL1TR002384] Funding Source: NIH RePORTER. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Bhupathiraju, NVSDK; Younes, A; Cao, MH; Ali, J; Cicek, HT; Tully, KM; Ponnala, S; Babich, JW; Deri, MA; Lewis, JS; Francesconi, LC; Drain, CM. The CAS is 104-10-9. Through research, I have a further understanding and discovery of 2-(4-Aminophenyl)ethanol. COA of Formula: C8H11NO
The bifunctional ligand p-SCN-Bn-HOPO, which has four 1,2-hydroxypyridinone groups on a spermine backbone with an isothiocyanate linker, has been shown to be an efficient and stable chelator for Zr(iv) and, more importantly, the radioisotope Zr-89 for use in radiolabeling antibodies for positron emission tomography (PET) imaging. Previous studies of Zr-89-HOPO-trastuzumab in mice showed low background, good tumor to organ contrast, and very low bone uptake which show p-SCN-Bn-HOPO to be an important next-generation bifunctional chelator for radioimmunoPET imaging with Zr-89. However, the reported synthesis of p-SCN-Bn-HOPO involves nine steps and multiple HPLC purifications with an overall yield of about 1.4%. Herein we report an improved and efficient synthesis of p-SCN-Bn-HOPO in four steps with 14.3% overall yield which will improve its availability for further biological studies and wider application in PET imaging. The new synthetic route also allows variation in linker length and chemistries which may be helpful in modifying in vivo clearance behaviors of future agents.
COA of Formula: C8H11NO. Welcome to talk about 104-10-9, If you have any questions, you can contact Bhupathiraju, NVSDK; Younes, A; Cao, MH; Ali, J; Cicek, HT; Tully, KM; Ponnala, S; Babich, JW; Deri, MA; Lewis, JS; Francesconi, LC; Drain, CM or send Email.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics