Recently I am researching about MAGNETIC-RESONANCE-SPECTROSCOPY; POSITRON-EMISSION-TOMOGRAPHY; PROSTATE-CANCER; RADIATION-DOSIMETRY; LUNG-CANCER; IN-VITRO; METABOLISM; F-18-FLUOROCHOLINE; DIAGNOSIS; CELLS, Saw an article supported by the Czech Science FoundationGrant Agency of the Czech Republic [19-01602S]; Ministry of Health of the Czech RepublicMinistry of Health, Czech Republic [16-30544A]; Ministry of Education, Youth and Sports of the Czech RepublicMinistry of Education, Youth & Sports – Czech Republic [LM2015064 EATRIS-CZ, LO1304, CZ.02.1.01/0.0/0.0/16_013/0001818, CZ.02.1.01/0.0/0.0/16_019/0000868]; Technology Agency of the Czech Republic [TE01020028]; Charles University Grant Agency [766119]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Svec, P; Novy, Z; Kucka, J; Petrik, M; Sedlacek, O; Kuchar, M; Liskova, B; Medvedikova, M; Kolouchova, K; Groborz, O; Loukotova, L; Konefal, RL; Hajduch, M; Hruby, M. The CAS is 104-10-9. Through research, I have a further understanding and discovery of 2-(4-Aminophenyl)ethanol. Product Details of 104-10-9
We present a novel series of radioiodinated tracers and potential theranostics for diseases accompanied by pathological function of proteins involved in choline transport. Unlike choline analogues labeled with C-11 or F-18 that are currently used in the clinic, the iodinated compounds described herein are applicable in positron emission tomography, single-photon emission computed tomography, and potentially in therapy, depending on the iodine isotope selection. Moreover, favorable half-lives of iodine isotopes result in much less challenging synthesis by isotope exchange reaction. Six of the described compounds were nanomolar ligands, and the best compound possessed an affinity 100-fold greater than that of choline. Biodistribution data of I-125-labeled ligands in human prostate carcinoma bearing (PC-3) mice revealed two compounds with a biodistribution profile superior to that of [F-18]fluorocholine.
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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics