Recently I am researching about N-H BONDS; BRONSTED ACID; METAL CATALYSIS; AMINATION; INSERTION; DERIVATIVES; COMPLEXES; CARBENE; MODE, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21402005, 91956114]; Beijing Municipal Natural Science FoundationBeijing Natural Science Foundation [2202040]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [XK-1802-6, 12060093063]; Research Grants Council of Hong KongHong Kong Research Grants Council [16302617, 16302318]; Hong Kong Scholars Program. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Guo, WG; Luo, YZ; Sung, HHY; Williams, ID; Li, PF; Sun, JW. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine. Safety of Diphenylmethanamine
Herein we disclose a new catalytic asymmetric approach for the synthesis of chiral alpha-amino ketones, which is particularly useful for the less accessible acyclic alpha-tertiary cases. By a protonation-amination sequence, our approach represents a rare asymmetric H-heteroatom bond insertion by alpha-carbonyl sulfonium ylides, an attractive surrogate of diazocarbonyls. The mild intermolecular C-N bond formation was catalyzed by chiral phosphoric acids with excellent efficiency and enantioselectivity. The products are precursors to other important chiral amine derivatives, including drug molecules and chiral ligands. The enantioselectivity was controlled by dynamic kinetic resolution in the amination step, rather than the initial protonation. This process opens up a new platform for the development of other related insertion reactions.
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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics