Product Details of 91-00-9. Recently I am researching about CATALYZED OXIDATIVE CARBONYLATION; DEALKYLATIVE CARBONYLATION; EFFICIENT SYNTHESIS; COUPLING REACTIONS; FUNCTIONALIZATION; PALLADIUM; ACTIVATION; ARYLATION; ACIDS; AMINOCARBONYLATION, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [NSFC 21702211, 21773051, 21703051, 21801056]; Natural Science Foundation of Jiangsu ProvinceNatural Science Foundation of Jiangsu Province [BK20170421]; Zhejiang Provincial Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province [LZ18B020001, LY17B030005]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Mu, QC; Nie, YX; Bai, XF; Chen, J; Yang, L; Xu, Z; Li, L; Xia, CG; Xu, LW. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine
A novel Pd/Cu-cocatalyzed carbonylative cyclization by C-H activation and N-dealkylative C-N bond activation has been developed for the chemoselective construction of synthetically useful heterocycles. The N,N-dimethylamine group on o-indolyl-N,N-dimethylarylamines was found to act as both the directing group and reactive component in this C-H carbonylative cyclization reaction. Furthermore, a unique C-H oxidation/carbonylative lactonization of diarylmethylamines is firstly demonstrated under modified reaction conditions, which could be easily applicable to the one-step synthesis of multi-substituted phthalides bearing an N,O-ketal skeleton that is difficult to access by previously reported methods. Mechanistic studies implicate that Pd/Cu-cocatalyzed C-H oxidation/carbonylative lactonization is a sequential reaction system via Cu-catalyzed C(sp(3))-H oxidation and Pd-catalyzed oxidative carbonylation of the C(sp(2))-H bond. It was found that trace amounts of water are essential to promote the Cu-catalyzed C(sp(3))-H oxidation of diarylmethylamine for the formation of the hydroxyl group, which could act as an in situ-formed directing group in the intramolecular carbonylative lactonization step.
Product Details of 91-00-9. Welcome to talk about 91-00-9, If you have any questions, you can contact Mu, QC; Nie, YX; Bai, XF; Chen, J; Yang, L; Xu, Z; Li, L; Xia, CG; Xu, LW or send Email.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics