In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 17193-28-1 as follows. Safety of 1-Amino-1-cyclopentanecarboxamide
N,N-Diisopropylethylamine (0.77 mL, 4.40 mmol) was added to a solution of commercially available ((S)-5-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-((tert-butoxycarbonyl)amino)pentanoic acid, 4 (1 g, 2.2 mmol), 1-aminocyclopentanecarboxamide, 9 (0.282 g, 2.2 mmol) and HATU (1.255 g, 3.30 mmol) in dry acetonitrile (20 mL) at room temperature under Argon atmosphere and the resulted reaction mixture was stirred under the same conditions for 2h. The progress of the reaction was monitored by TLC. Solvent was evaporated under reduced pressure and the crude product was purified on Teledyne Isco Combiflash Rf purification machine to provide (9H-fluoren-9-yl)methyl tert-butyl (5-((1-carbamoylcyclopentyl)amino)-5-oxopentane-1,4-diyl)(S)-dicarbamate, 10 (1.18 g, 95%) as a colorless solid. ESI-MS m/z: 565.3 [M+H]+. 1H NMR (400 MHz, DMSO-d6): delta 8.02 (s, 1H, NH), 7.89 (d, J=7.4 Hz, 2H, ArH), 7.67 (d, J=7.4 Hz, 2H, ArH), 7.43-7.27 (m, 5H, ArH, NHFmoc), 7.02 (d, J=6.2 Hz, 1H, NHBoc), 6.87 (bs, 1H, CONH2), 6.85 (bs, 1H, CONH2), 4.28 (d, J=6.1 Hz, 2H, FmocCH2), 4.20 (t, J=6.8 Hz, 1H, FmocCH), 3.80 (q, J=6.8 Hz, 1H, NHCH), 2.96 (q, J=6.3 Hz, 2H, CH2NHFmoc), 2.12-1.83 (m, 4H, CH2), 1.65-1.30 (m, 17H, CH2, Boc).
According to the analysis of related databases, 17193-28-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SOUTHERN RESEARCH INSTITUTE; UAB RESEARCH FOUNDATION; Suto, Mark J.; Gupta, Vandana; Mathew, Bini; Murphy-Ullrich, Joanne; (105 pag.)US2019/127420; (2019); A1;,
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