The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole(SMILESS: CN1N=C(CCl)C=C1,cas:84547-64-8) is researched.Recommanded Product: 84547-64-8. The article 《Synthesis of new proton-pump inhibitors (2) and tests for it’s biological activity》 in relation to this compound, is published in Chungnam Kwahak Yonguchi. Let’s take a look at the latest research on this compound (cas:84547-64-8).
For development new anti-ulcer agents, we synthesized proton-pump (H+/K+-ATPase) inhibitors which inhibit gastric acid secretion at the last step in the parietal cell. These are omeprazole analogs, in which pyridine group is replaced by pyrazole moiety, to increase pharmacol. activity and to decrease side effects, and we also synthesized substituted benzimidazole rings. The structure of the compounds was identified with 1H-NMR, M.S. and I.R. The compounds with 5-substituted benzimidazoles showed good activity in the following order MeO > Cl > H, and also, 1-benzyl group of pyrazole substituted compounds has enhanced activity.
After consulting a lot of data, we found that this compound(84547-64-8)Reference of 3-(Chloromethyl)-1-methyl-1H-pyrazole can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics