The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole( cas:84547-64-8 ) is researched.Recommanded Product: 84547-64-8.Kim, Hyo-Jeong; Kwon, Tae-Ik; Park, Il-Hyun published the article 《Synthesis of new proton-pump inhibitors (2) and tests for it’s biological activity》 about this compound( cas:84547-64-8 ) in Chungnam Kwahak Yonguchi. Keywords: antiulcer agent omeprazole analog preparation. Let’s learn more about this compound (cas:84547-64-8).
For development new anti-ulcer agents, we synthesized proton-pump (H+/K+-ATPase) inhibitors which inhibit gastric acid secretion at the last step in the parietal cell. These are omeprazole analogs, in which pyridine group is replaced by pyrazole moiety, to increase pharmacol. activity and to decrease side effects, and we also synthesized substituted benzimidazole rings. The structure of the compounds was identified with 1H-NMR, M.S. and I.R. The compounds with 5-substituted benzimidazoles showed good activity in the following order MeO > Cl > H, and also, 1-benzyl group of pyrazole substituted compounds has enhanced activity.
Different reactions of this compound(3-(Chloromethyl)-1-methyl-1H-pyrazole)Recommanded Product: 84547-64-8 require different conditions, so the reaction conditions are very important.
Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics