Basson, Ashley J.; McLaughlin, Mark G. published the artcile< Synthesis of Functionalized Isoindolinones via Calcium Catalyzed Generation and Trapping of N-Acyliminium Ions>, Computed Properties of 1524-40-9, the main research area is calcium catalyst acyliminium ion hydroxyisoindolinone nucleophilic addition; isoindolinone preparation.
Herein we report our full investigation into the calcium catalyzed generation and trapping of N-acyliminium ions from readily available 3-hydroxyisoindolinones. We have successfully employed a range of traditional nucleophiles including carbon, nitrogen, and sulfur containing reactive partners. The reaction is tolerant to a wide range of functionalities and provides high value scaffolds in good to excellent yields.
Journal of Organic Chemistry published new progress about Nucleophilic addition reaction. 1524-40-9 belongs to class amides-buliding-blocks, and the molecular formula is C6H6FNO2S, Computed Properties of 1524-40-9.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics