Printsevskaya, S. S.; Olsuf’eva, E. N.; Lazhko, E. I.; Preobrazhenskaya, M. N. published their research in Russian Journal of Bioorganic Chemistry (Translation of Bioorganicheskaya Khimiya) on February 28 ,2002. The article was titled 《Antibiotic N’,N”-dibenzyleremomycin with a reduced 1,2-peptide bond》.HPLC of Formula: 87694-50-6 The article contains the following contents:
Eremomycin derivatives with benzylated amino groups of both residues of eremosamine and with (R) or (S)-2-amino-4-methylpentyl substituted for N-methyl-D-Leu, the first amino acid residue of its heptapeptide, were synthesized in order to study the role of the peptide bond between the first and second amino acid residues of the heptapeptide moiety of the antibiotic in its interaction with the precursors of the bacterial cell wall peptidoglycan and the exhibition of its antibacterial activity. Comparison of the antibacterial activities of N’,N”-dibenzyleremomycin (I, R = N-Me-D-Leu), de-(N-methyl-D-Leu)-N’,N”-dibenzyleremomycin (I, R = H), and its stereoisomeric N-(2-amino-4-methylpentyl)-derivatives (1,2-deoxo-N’,N”-dibenzyleremomycin) (I, R = 2-amino-4-methylpentyl) demonstrated that cleavage or replacement of the first amino acid residue by the corresponding aminoalkyl residue results in a decrease in its antibacterial activity towards both vancomycin-sensitive and vancomycin-resistant strains of microorganisms. After reading the article, we found that the author used (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6HPLC of Formula: 87694-50-6)
(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents.HPLC of Formula: 87694-50-6
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics