Reference of 24243-71-8, A common heterocyclic compound, 24243-71-8, name is Propane-1-sulfonamide, molecular formula is C3H9NO2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
[0171] NaH (60% in mineral oil, 80 mg, 1.99 mmol) was slowly added to a solution of propane-i-sulfonamide (226 mg, 1.84 mmol) in DMF (20.0 mL) at 0 C. The reaction mixture was degassed with N2 and stirred at room temperature for 60 mm. Then 9-(3-fluoro- 2-nitrophenoxy)-2,3-dihydroimidazo[i,2-cjquinazoline (500 mg, 1.53 mmol) was added and the mixture was stirred at 80 C overnight under N2. The resulting mixture was evaporated and the residue was purified by flash column (ACN/H20) to afford N-(3-((2,3- dihydroimidazo [1 ,2-cjquinazolin-9-yl)oxy)-2-nitrophenyl)propane- i-sulfonamide (240 mg, 37% yield) as a yellow solid. ?H NMR (400 MHz, DMSO-d6): 8.24 (s, 1H), 7.67 (d, J = 8.8 Hz, 1H), 7.57-7.51 (m, 2H), 7.39-7.32 (m, 2H), 6.68 (d, J= 7.2 Hz, 1H), 4.34 (t, J= 10.0 Hz, 2H), 4.00 (t, J= 10.0 Hz, 2H), 2.96 (t, J= 7.6 Hz, 2H), 1.72-1.66 (m, 2H), 0.96 (t, J= 7.6 Hz, 3H). LCMS (M+H) mlz: 430.1.
The synthetic route of 24243-71-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ABM THERAPEUTICS, INC.; CHEN, Chen; (154 pag.)WO2019/60611; (2019); A1;,
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