Kim, Dae Hun; Maharjan, Pooja; Kim, Jae Yeol; Jang, Dong-Jin; Koo, Tae-Sung; Min, Kyoung Ah; Cho, Kwan Hyung published the artcile< Enhanced solubility, in-vitro dissolution and lipase inhibition of a self-nanoemulsifying drug delivery system containing orlistat>, Recommanded Product: (S)-(S)-1-((2S,3S)-3-Hexyl-4-oxooxetan-2-yl)tridecan-2-yl 2-formamido-4-methylpentanoate, the main research area is orlistat lipase solubility dissolution gastrointestinal lumen SNEDDS.
The aim of this work was to prepare and assess a self-nanoemulsifying drug delivery system (SNEDDS) containing water-insoluble orlistat that was used for the inhibition of lipase activity in gastrointestinal lumen. The pseudo-ternary phase diagram, composed of orlistat and medium chain triglycerides (MCT) as oil phase and Cremophor EL as surfactant, was made for the confirmation of giving SNEDDS preconc. The phys. state, particle size dispersed in water, dissolution and lipase inhibition of SNEDDS preconcs. were investigated. The appointed SNEDDS preconcs. in the pseudo-ternary phase diagram showed no endothermic peak of orlistat and a liquid state. The particle sizes of SNEDDS dispersed with water were uniform and in the range of <200 nm. In the dissolution test, the liquid SNEDDS preconc. and solid state mixture exhibited 90.89 ± 2.03% vs. 22.42 ± 3.71% at 60 min., resp., whereas the raw orlistat showed no significant dissolution rate. The SNEDDS preconc. showed a lipase inhibition of 92.42 ± 1.58% until 60 min., with no significant inhibition activity of orlistat. Therefore, the SNEDDS preconc. presented in this work solubilized orlistat and increased its dissolution rate, and resulted in sufficient inhibitory action on lipase. Journal of Nanoscience and Nanotechnology published new progress about Castor oil, ethoxylated Role: MOA (Modifier or Additive Use), PAC (Pharmacological Activity), THU (Therapeutic Use), USES (Uses), BIOL (Biological Study). 96829-58-2 belongs to class amides-buliding-blocks, and the molecular formula is C29H53NO5, Recommanded Product: (S)-(S)-1-((2S,3S)-3-Hexyl-4-oxooxetan-2-yl)tridecan-2-yl 2-formamido-4-methylpentanoate.
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