Huang, Yazhong; Knouse, Kyle W.; Qiu, Shenjie; Hao, Wei; Padial, Natalia M.; Vantourout, Julien C.; Zheng, Bin; Mercer, Stephen E.; Lopez-Ogalla, Javier; Narayan, Rohan; Olson, Richard E.; Blackmond, Donna G.; Eastgate, Martin D.; Schmidt, Michael A.; McDonald, Ivar M.; Baran, Phil S. published the artcile< A P(V) platform for oligonucleotide synthesis>, Quality Control of 1192620-83-9, the main research area is DNA LNA preparation phosphodiester phosphorodithioate human; crystal structure DNA preparation phosphodiester phosphorodithioate nucleotide polymer.
The promise of gene-based therapies is being realized at an accelerated pace, with more than 155 active clin. trials and multiple U.S. Food and Drug Administration approvals for therapeutic oligonucleotides, by far most of which contain modified phosphate linkages. These unnatural linkages have desirable biol. and phys. properties but are often accessed with difficulty using phosphoramidite chem. We report a flexible and efficient [P(V)]-based platform that can install a wide variety of phosphate linkages at will into oligonucleotides. This approach uses readily accessible reagents and can install not only stereo-defined or racemic thiophosphates but any combination of (S, R or rac)-PS with native phosphodiester (PO2) and phosphorodithioate (PS2) linkages into DNA and other modified nucleotide polymers. This platform easily accesses this diversity under a standardized coupling protocol with prepared and stable P(V) reagents.
Science (Washington, DC, United States) published new progress about Coupling reaction. 1192620-83-9 belongs to class amides-buliding-blocks, and the molecular formula is C30H31ClN2O2RuS, Quality Control of 1192620-83-9.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics