In 2011,Aubry, Sylvain; Sasaki, Kaname; Eloy, Laure; Aubert, Genevieve; Retailleau, Pascal; Cresteil, Thierry; Crich, David published 《Exploring the potential of the β-thiolactones in bioorganic chemistry》.Organic & Biomolecular Chemistry published the findings.Product Details of 71432-55-8 The information in the text is summarized as follows:
A series of novel peptide-based β-thiolactones were synthesized and assayed for cytotoxicity against several human cancer cell lines, where they showed greater activity than the corresponding β-lactones and β-lactams. Several of the β-thiolactones prepared showed strong inhibitory activity in vitro against human cathepsins B and L. In the experiment, the researchers used tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8Product Details of 71432-55-8)
tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Product Details of 71432-55-8
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics