The author of 《Synthesis and Antimicrobial and Antioxidant Activities of Sulfonamide Derivatives Containing Tetrazole and Oxadiazole Rings》 were Ozkan, Hamdi; Demirci, Bayram. And the article was published in Journal of Heterocyclic Chemistry in 2019. Recommanded Product: 4-Methylbenzenesulfonamide The author mentioned the following in the article:
A new sulfonamide derivative with 1,3,4-oxadiazole moiety and tetrazole ring. I [R = 4-FC6H4S(O)2NH, 4-H3CC6H4S(O)2NH, (4-sulfamoylphenyl)aminyl, etc.] have been synthesized. The biol. activities of resulting compound were also investigated and observed that the compounds reveal strong antimicrobial activity over some important bacterial strains including Bacillus subtilis ATCC 6633, Escherichia coli ATCC 25922, Klebsiella pneumoniae ATCC 13883, and Staphylococcus aureus ATCC 29213. The in vitro antifungal properties of synthesized compounds I, II and III [R1 = H, 2,2-dimethyl-2-((1-[(5-sulfanyl-1,3,4-oxadiazol-2-yl)methyl]-1H-1,2,3,4-tetrazol-5-yl)carbamoyl)ethyl] were also a target using Candida albicans NRRL Y-477 and Saccharomyces cerevisiae fungal strains. A useful guideline for future studies about the effect of the chem. structures of sulfonamide compounds on the biol. activities have been provided. Among the target compounds, I (R = 4-FC6H4S(O)2NH, 4-ClC6H4S(O)2NH, 4-BrC6H4S(O)2NH, 4-IC6H4S(O)2NH) demonstrated surprisingly high antimicrobial activities than did others. In the experimental materials used by the author, we found 4-Methylbenzenesulfonamide(cas: 70-55-3Recommanded Product: 4-Methylbenzenesulfonamide)
4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Recommanded Product: 4-Methylbenzenesulfonamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics