Application of 70-55-3In 2019 ,《Multicomponent Aromatic and Benzylic Mannich Reactions through C-H Bond Activation》 was published in Chemistry – A European Journal. The article was written by Xavier, Tania; Rayapin, Corinne; Le Gall, Erwan; Presset, Marc. The article contains the following contents:
The straightforward generation of densely substituted-amines I [R = H, Me; R1 = Me, 4-MeC6H4, 2-thienyl; R2 = Ph, 4-MeC6H4, 2-thienyl, etc.; R3 = H, 3-Me, 4-OMe, etc.] was described via multicomponent Mannich reaction of sulfonamides, acetals and arylpyridines through C-H bond activation in good yields. The reaction involved a reaction between two transient species: an organometallic species, generated by transition-metal-catalyzed sp2 or sp3 C-H bond activation and an in situ generated imine. The use of an acetal as an aldehyde surrogate was found essential for the reaction to proceed. The process could be successfully applied to RhIII-catalyzed sp2 C-H bond functionalization and extended to CuII-catalyzed sp3 C-H bond functionalization. In the part of experimental materials, we found many familiar compounds, such as 4-Methylbenzenesulfonamide(cas: 70-55-3Application of 70-55-3)
4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Application of 70-55-3
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics