《Preparation of Primary Amides from Functionalized Organozinc Halides》 was written by Schade, Matthias A.; Manolikakes, Georg; Knochel, Paul. Quality Control of 2,6-Dichloroisonicotinamide And the article was included in Organic Letters on August 20 ,2010. The article conveys some information:
Organozinc halides, which are prepared either by direct zinc insertion or halogen-magnesium exchange and subsequent transmetalation with ZnCl2, react smoothly with com. available trichloroacetyl isocyanate to give, after hydrolysis, the corresponding primary amides. This method is compatible with a variety of functional groups such as an ester or a cyano group. Also heterocyclic-, alkenyl, and acetylenic zinc reagents are converted to the corresponding primary amides under these conditions. In the part of experimental materials, we found many familiar compounds, such as 2,6-Dichloroisonicotinamide(cas: 89281-13-0Quality Control of 2,6-Dichloroisonicotinamide)
2,6-Dichloroisonicotinamide(cas: 89281-13-0) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Quality Control of 2,6-Dichloroisonicotinamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics