On January 27, 2017, Mancini, Alessandra; Chelini, Alessia; Di Capua, Angela; Castelli, Loretta; Brogi, Simone; Paolino, Marco; Giuliani, Germano; Cappelli, Andrea; Frosini, Maria; Ricci, Lorenzo; Leonelli, Erminia; Giorgi, Gianluca; Giordani, Antonio; Magistretti, Jacopo; Anzini, Maurizio published an article.Application In Synthesis of N,N-Diethylacetamide The title of the article was Synthesis and biological evaluation of a new class of benzothiazines as neuroprotective agents. And the article contained the following:
The synthesis of differently functionalized 4H-3,1-benzothiazine I and 2H-1,4-benzothiazine II [X = CH2, S; Y = CH2, S; R = H, OCF3; R1 = R2 = H, Me, Et, n-Pr] series as superior homologs of rizuline were reported. Biol. evaluation demonstrated that amidine 4H-3,1-benzothiazine derivatives I [R1 = R2 = H, Et, n-Pr] reduces glutamate and LDH release in the oxygen/glucose deprivation and reperfusion model (OGD/R) applied to brain slices with a higher potency than rizuline. Moreover the mentioned compounds significantly reduced glutamate- and 6-hydroxydopamine (6-OHDA)-induced cytotoxicity in neuroblastoma cells. In addition, the same compounds limit ROS formation in both neuronal preparations Finally, compound I [R1 = R2 = Et] proved effective in inhibiting neuronal voltage-dependent Na+ and Ca2+-channels, showed a profile comparable with that of rizuline. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Application In Synthesis of N,N-Diethylacetamide
The Article related to benzothiazinyl acetamidine preparation neuroprotective agent antioxidant sar, propylthiourea benzothiazinyl preparation neuroprotective agent antioxidant sar, benzothiazine derivatives, neurodegenerative diseases, neuronal voltage-dependent na(+) and ca(2+) currents, neuroprotective agents, sh-sy5y cells and other aspects.Application In Synthesis of N,N-Diethylacetamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics