On March 5, 2020, Krainc, Dimitri; Silverman, Richard B.; Zheng, Jianbin published a patent.SDS of cas: 16230-24-3 The title of the patent was Preparation of pyrrolopyrimidine compounds and uses thereof for modulating glucocerebrosidase activity. And the patent contained the following:
The invention relates to preparation of new small mols. having a pyrrolopyrimidine (I) core structure and the uses thereof for modulating glucocerebrosidase activity. Compounds I wherein m is o-6; R1 is aryl, heteroaryl, etc.; R2 is C1-6 alkyl or pyridinyl, are claimed. The example compound II was prepared via 3-step synthesis (procedure given). Also disclosed are pharmaceutical compositions comprising the small mols. which may be administered in methods of treating diseases or disorders associated with glucocerebrosidase activity, including neurol. diseases and disorders such as Gaucher’s disease and Parkinson’s disease. Compounds I may be utilized to generate activated glucocerebrosidase. The activated glucocerebrosidase can be administered in enzyme replacement therapy and/or utilized in screening assays for new small mols. that bind to the activated glucocerebrosidase and/or modulate the activity of the activated glucocerebrosidase. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).SDS of cas: 16230-24-3
The Article related to pyrrolopyrimidine preparation glucocerebrosidase modulator neurodegenerative metabolic disease treatment, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.SDS of cas: 16230-24-3
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics