Bonciolini, Stefano; Di Filippo, Mara; Baumann, Marcus published an article in 2020, the title of the article was A scalable continuous photochemical process for the generation of aminopropylsulfones.Category: amides-buliding-blocks And the article contains the following content:
An efficient continuous photochem. process that delivers a series of novel 纬-aminopropylsulfones RSO2CH2CH2CH(R1)N(R2)C(O)R3 (R = Ph, Et; R1 = H, Me; R2 = Me, Et; R3 = H, Ph, cyclohexyl, etc.) and RSO2CH2CH2CH(O)NHMe via a tetrabutylammonium decatungstate (TBADT) catalyzed HAT-process is presented. Crucial to this success is the exploitation of a new high-power LED emitting at 365 nm that was found to be superior to an alternative medium-pressure Hg lamp. The resulting flow process enabled the scale-up of this transformation reaching throughputs of 20 mmol h-1 at substrate concentrations up to 500 mM. Addnl., the substrate scope of this transformation was evaluated demonstrating the straightforward incorporation of different amine substituents as well as alkyl appendages next to the sulfone moiety. It is anticipated that this methodol. will allow for further exploitations of these underrepresented 纬-aminopropylsulfone scaffolds in the future. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Category: amides-buliding-blocks
The Article related to aminopropylsulfone preparation, amide vinyl sulfone coupling reaction tetrabutylammonium decatungstate photocatalyst, General Organic Chemistry: Synthetic Methods and other aspects.Category: amides-buliding-blocks
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics