Author: Jessica.F

Marae, Islam S. published the artcileSynthesis, characterization and crystal structure of some novel partially hydrogenated isoquinolines and their fused heterocyclic systems, Application of 2-Chloroacetamide, the publication is Journal of Heterocyclic Chemistry (2022), 59(7), 1230-1240, database is CAplus.

Ketonic hydrolysis of 7-acetyl-4-cyano-1,6-dimethyl-6-hydroxy-8-phenyl-5,6,7,8-tetrahydro-isoquinoline-3(2H)-thione via heating with aqueous solution of potassium hydroxide resulted in both deacetylation and dehydration affording new 7,8-dihydroisoquinoline scaffold (7,8-DHISQ) I. Two simple mechanistic approaches are postulated for this synthesis. One of them was supported by converting II into I via heating with aqueous solution of potassium hydroxide. I was used as a key intermediate for synthesizing other 7,8-DHISQ’s III and IV, as well as 7,8-dihydrothienoisoquinoline. Reaction of compound II with 2-chloroacetamide by refluxing in ethanol containing sodium acetate gave 7-acetyl-1-amino-5,8-dimethyl-6-phenyl-6,7-dihydrothieno[2,3-c] isoquinoline-2-carboxamide which was converted into full aromatized pyrimidothienoisoquinoline on treatment with tri-Et orthoformate. Reaction of II with both hydrazine hydrate and hydroxylamine hydrochloride afforded tetrahydropyrazolo-isoquinoline and tetrahydroisoxazoloisoquinoline, resp. Reaction of tetrahydroisoxazoloisoquinoline with N-(4-chlorophenyl)-2-chloroacetamide produced (N-phenylcarbamoylmethylthio)tetra-hydroisoxazoloisoquinoline which was converted into tetrahydroisoxazolothieno-isoquinoline upon heating with sodium ethoxide. Also, crystal structures of compounds III and another tetrahydropyrazoloisoquinoline were determined via X-rays diffraction anal.

Journal of Heterocyclic Chemistry published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Application of 2-Chloroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Adrian, Rafael A. published the artcileBis(isonicotinamide-κN)silver(I) trifluoromethanesulfonate acetonitrile disolvate, Application In Synthesis of 1453-82-3, the publication is IUCrData (2021), 6(10), x211073, database is CAplus.

The central AgI atom of the title salt, [Ag(INAM)₂](CF₃SO₃)·2CH₃CN, where INAM is isonicotinamide (C₆H₆N₂O), is twofold coordinated by the pyridine N atoms of two isonicotinamide ligands creating a slightly distorted linear mol. geometry. The formation of polymeric chains {[Ag(INAM)₂]⁺}_n, held together by discrete hydrogen bonds through the amide group of the INAM ligand leaves voids for non-coordinating acetonitrile mols. that interact the silver metal center via regium bonds.

IUCrData published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Application In Synthesis of 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Stamou, Aggeliki published the artcileNIPAm-Based Modification of Poly(L-lysine): A pH-Dependent LCST-Type Thermo-Responsive Biodegradable Polymer, Application of H-Lys(Boc)-OH, the publication is Polymers (Basel, Switzerland) (2022), 14(4), 802, database is CAplus and MEDLINE.

Polylysine is a biocompatible, biodegradable, water soluble polypeptide. Thanks to the pendant primary amines it bears, it is susceptible to modification reactions. In this work Poly(L-lysine) (PLL) was partially modified via the effortless free-catalyzed aza-Michael addition reaction at room temperature by grafting N-isopropylacrylamide (NIPAm) moieties onto the amines. The resulting PLL-g-NIPAm exhibited LCST-type thermosensitivity. The LCST can be tuned by the NIPAm content incorporated in the macromols. Importantly, depending on the NIPAm content, LCST is highly dependent on pH and ionic strength due to ionization capability of the remaining free lysine residues. PLL-g-NIPAm constitutes a novel biodegradable LCST polymer that could be used as “smart” block in block copolymers and/or terpolymers, of any macromol. architecture, to design pH/Temperature-responsive self-assemblies (nanocarriers and/or networks) for potential bio-applications.

Polymers (Basel, Switzerland) published new progress about 2418-95-3. 2418-95-3 belongs to amides-buliding-blocks, auxiliary class Chiral,Carboxylic acid,Amine,Aliphatic hydrocarbon chain,Ester,Amino acide derivatives, name is H-Lys(Boc)-OH, and the molecular formula is C18H10, Application of H-Lys(Boc)-OH.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Pearson, Caroline A. published the artcileWhen the BBB goes MIA, Application In Synthesis of 169590-42-5, the publication is Proceedings of the National Academy of Sciences of the United States of America (2022), 119(19), e2204159119, database is CAplus and MEDLINE.

A review. Epidemiol. studies implicate maternal immune activation (MIA) as a risk factor for a variety of neurodevelopmental disorders. Early MIA results in BBB disruption and inflammatory responses that lead to persistent postnatal structural and cellular defects associated with MIA, rescuable by celecoxib treatment. The findings advance our understanding of the developmental origins of MIA-associated cognitive deflicits and unveil a potential therapeutic intervention for the BBB dysfunction and chronic inflammation associated with neurodevelopmental disease. In addition, the data raise the possibility that the BBB alterations induced by MIA may also contribute to other diseases associated with chronic neuroinflammation. In this regard, MIA in the setting of the SARS-CoV-2 pandemic should alert health-care providers to this potential risk, warranting careful monitoring of the offspring in infected mothers.

Proceedings of the National Academy of Sciences of the United States of America published new progress about 169590-42-5. 169590-42-5 belongs to amides-buliding-blocks, auxiliary class Sulfamide,Immunology/Inflammation,COX, name is 4-(5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide, and the molecular formula is C17H14F3N3O2S, Application In Synthesis of 169590-42-5.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Zaiter, Samantha S. published the artcileDesigning de Novo Small Molecules That Control Heat Shock Protein 70 (Hsp70) and Heat Shock Organizing Protein (HOP) within the Chaperone Protein-Folding Machinery, HPLC of Formula: 2418-95-3, the publication is Journal of Medicinal Chemistry (2019), 62(2), 742-761, database is CAplus and MEDLINE.

Protein-protein interactions (PPIs) regulate all signaling pathways for cellular function. Developing mols. that modulate PPIs through the interface of their protein surfaces has been a significant challenge and there has been little success controlling PPIs through standard mol. library screening approaches. PPIs control the cell’s protein-folding machinery, and this machinery relies on a multi-protein complex formed with heat shock protein 70 (Hsp70). Described is the design, synthesis, and biol. evaluation of mols. aimed to regulate the interaction between two proteins that are critical to the protein-folding machinery: heat shock protein 70 (Hsp70) and cochaperone heat shock organizing protein (HOP). We report the first class of compounds that directly regulate these two protein-protein interactions and inhibit protein folding events.

Journal of Medicinal Chemistry published new progress about 2418-95-3. 2418-95-3 belongs to amides-buliding-blocks, auxiliary class Chiral,Carboxylic acid,Amine,Aliphatic hydrocarbon chain,Ester,Amino acide derivatives, name is H-Lys(Boc)-OH, and the molecular formula is C27H39ClN2, HPLC of Formula: 2418-95-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Neogi, Tuhina published the artcileObserved efficacy and clinically important improvements in participants with osteoarthritis treated with subcutaneous tanezumab: results from a 56-week randomized NSAID-controlled study, Name: 4-(5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide, the publication is Arthritis Research & Therapy (2022), 24(1), 78, database is CAplus and MEDLINE.

A recent phase 3 study demonstrated that treatment with tanezumab, a nerve growth factor inhibitor, or nonsteroidal anti-inflammatory drugs (NSAIDs) improves pain and phys. function in participants with moderate-to-severe osteoarthritis (OA) of the hip or knee. Here, we evaluated the time course and clin. importance of these initial efficacy findings using a mixture of primary, secondary, and post hoc endpoints. Participants on stable NSAID therapy and with a history of inadequate response to other standard OA analgesics were enrolled in an 80-wk (56-wk treatment/24-wk safety follow-up), randomized, NSAID-controlled, phase 3 study primarily designed to assess the safety of tanezumab for moderate-to-severe OA of the knee or hip. Participants received oral NSAID (twice daily naproxen, celecoxib, or diclofenac) or s.c. tanezumab (2.5mg or 5mg every 8 wk). Non-responders were discontinued at week 16. Changes from baseline in WOMAC Pain and Phys. Function, Patients Global Assessment of Osteoarthritis (PGA-OA), and average pain in the index joint were compared between tanezumab and NSAID groups over the 56-wk treatment period. Clin. meaningful response (e.g., ≥30% and ≥50% improvement in WOMAC Pain and Phys. Function), rescue medication use, and safety were also assessed. All groups improved WOMAC Pain, WOMAC Phys. Function, PGA-OA, and average pain in the index joint over the 56-wk treatment period relative to baseline. Across all groups, improvements generally occurred from the time of first assessment (week 1 or 2) to week 16 and then slightly decreased from week 16 to 24 before stabilizing from weeks 24 to 56. The magnitude of improvement and the proportion of participants achieving ≥30% and ≥50% improvement in these measures was greater (unadjusted p≤0.05) with tanezumab than with NSAID at some timepoints on or before week 16. Adverse events of abnormal peripheral sensation, prespecified joint safety events, and total joint replacement surgery occurred more frequently with tanezumab than with NSAID. Tanezumab and NSAID both provided early and sustained (up to 56 wk) efficacy relative to baseline. Improvements in pain and function were clin. meaningful in a substantial proportion of participants. Adverse events of abnormal peripheral sensation and joint safety events occurred more frequently with tanezumab than with NSAID. Trial registration: ClinicalTrials.govNCT02528188. Registered on 19 July 2015.

Arthritis Research & Therapy published new progress about 169590-42-5. 169590-42-5 belongs to amides-buliding-blocks, auxiliary class Sulfamide,Immunology/Inflammation,COX, name is 4-(5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide, and the molecular formula is C17H14F3N3O2S, Name: 4-(5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Fritz, H. published the artcileStudies on organophosphorus compounds. XXVI. Synthesis and carbon-13 NMR spectra of N,N-dialkyl thioamides, Category: amides-buliding-blocks, the publication is Bulletin des Societes Chimiques Belges (1978), 87(7), 525-34, database is CAplus.

By a new sulfuration reagent, the dimer of p-methoxyphenylthionophosphine sulfide, a series of thioamides were prepared in almost quant. yields from the corresponding amides. Carbon-13 NMR spectra of tertiary thioamides of formic, acetic, trifluoroacetic, propionic, and butyric acids were completely assigned with the aid of extensive double resonance and shift reagent experiments and the data obtained were compared with those of the analogous amides. A linear relation between the carbon-13 chem. shifts of the C:S of ethylthioamides and C:O of the corresponding amide was found.

Bulletin des Societes Chimiques Belges published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Category: amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Gross, Annika published the artcileA Ruthenocene-PNA Bioconjugate – Synthesis, Characterization, Cytotoxicity, and AAS-Detected Cellular Uptake, Name: 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(2-(((benzhydryloxy)carbonyl)amino)-6-oxo-5H-purin-9(6H)-yl)acetamido)acetic acid, the publication is Bioconjugate Chemistry (2012), 23(9), 1764-1774, database is CAplus and MEDLINE.

Labeling of peptide nucleic acids (PNA) with metallocene complexes is explored herein for the modulation of the anal. characteristics, as well as biol. properties of PNA. The synthesis of the first ruthenocene-PNA conjugate with a dodecamer, mixed-sequence PNA is described, and its properties are compared to a ferrocene-labeled analog as well as an acetylated, metal-free derivative The synthetic characteristics, chem. stability, anal. and thermodn. properties, and the interaction with cDNA were investigated. Furthermore, the cytotoxicity of the PNA conjugates is determined on HeLa, HepG2, and PT45 cell lines. Finally, the cellular uptake of the metal-containing PNAs was quantified by high-resolution continuum source at. absorption spectrometry (HR-CS AAS). An unexpectedly high cellular uptake to final concentrations of 4.2 mM was observed upon incubation with 50 μM solutions of the ruthenocene-PNA conjugate. The ruthenocene label was shown to be an excellent label in all respects, which is also more stable than its ferrocene analog. Because of its high stability, low toxicity, and the lack of a natural background of ruthenium, it is an ideal choice for bioanal. purposes and possible medicinal and biol. applications like, e.g., the development of gene-targeted drugs.

Bioconjugate Chemistry published new progress about 186046-83-3. 186046-83-3 belongs to amides-buliding-blocks, auxiliary class Purine,Carboxylic acid,Amine,Benzene,Amide,Others,PNA,, name is 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(2-(((benzhydryloxy)carbonyl)amino)-6-oxo-5H-purin-9(6H)-yl)acetamido)acetic acid, and the molecular formula is C40H35N7O8, Name: 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(2-(((benzhydryloxy)carbonyl)amino)-6-oxo-5H-purin-9(6H)-yl)acetamido)acetic acid.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Pailer, Matthias published the artcileDetermination of primary and secondary amines as amides by means of gas chromatography on packed and capillary columns, COA of Formula: C6H10F3NO, the publication is Monatshefte fuer Chemie (1966), 97(6), 1541-53, database is CAplus.

A very large number of phthalyl, succinyl, trifluoroacetyl, and pentafluoropropionyl derivatives of primary and secondary amines were prepared in order to investigate their suitability for gas-chromatog. separation, in studies on tobacco smoke amines. The best results were obtained with trifluoroacetyl derivatives (Makisumi and Saroff, CA 62, 13847b). Cooled 0.01 mole amine in 5 ml. absolute Et2O was treated with 0.01 mole (CF3CO)2O at -5°. The mixture was kept for 1 hr. and treated with 20 ml. Et2O (CH2Cl2 for difficultly soluble derivatives) and processed as usual to give 90-5% of the following F3CCONR1R2 (R1, R2, m.p., b.p./mm., and n20D given): Me, H, 48-49.5°, 80°/11, -; Et, H, -, 90°/11, 1.3600; Pr, H, -, 100°/11, 1.3718; iso-Pr, H, 52-3°, 60°/0.01, -; allyl, H, -, 100°/11, 1.3849; CH:CH2, H, -, 95°/11, 1.3932; MeO(CH2)3, H, -, 110°/11, 1.3900; Bu, H, -, 105°/11, 1.3803; EtMeCH, H, -, 95°/11, 1.3802; iso-Bu, H, -, 95°/11, 1.3792; tert-Bu, H, 44-5°, 70°/11, -; Am, H, -, 110°/11, 1.3901; PrMeCH, H, -, 45°/0.001, 1.3879; Et2CH, H, 52-3°, 105°/11, -; EtMeCHCH2, H, -, 115°/11, 1.3910; iso-Am, H, -, 115°/11, 1.3890; n-C6H13, H, -, 120°/11, 1.3969; n-C7H15, H, -, 135°/11, 1.4031; n-C8H17, H, -, 160°/11, 1.4089; EtBuCHCH2, H, -, 80°/0.001, 1.4117; n-C13H27, H, 62-3°, 100°/0.001, -; n-C15H31, H, 72-3°, 120°/0.001, -; n-C16H33, H, 69-70°, 140°/0.001, -; n-C18H37, H, 70-2°, 150°/0.001, -; 9-octadecenyl, H, -, 140°/0.001, -; cyclopentyl, H, 73°, 80°/0.001, -; cyclohexyl, H, 94-4.5°, 80°/0.001, -; cycloheptyl, H, 61-2°, 80°/0.001, -; MePhCH, H, -, 70°/0.001, -; PhCH2CH2, H, 55-6°, 70°/0.001, -; PhCH2, H, 73.5-4.5°, 70°/0.001, -; styryl, H, 105-7°, 110°/0.001, -; Me, Me, -, 50°/11, 1.3632; Me, Et, -, 60°/11, 1.3741; Et, Et, -, 65°/11, 1.3798; Pr, Pr, -, 85°/11, 1.3938; iso-Pr, iso-Pr, 52-3°, 85°/11, -; Pr, iso-Pr, -, 85°/11, 1.3929; allyl, allyl, -, 90°/11, 1.4124; Bu, Bu, -, 110°/11, 1.4045; sec-Bu, sec-Bu, -, 95°/11, 1.4072; iso-Bu, iso-Bu, -, 95°/11, 1.4031; iso-Bu, Bu, -, 100°/11, 1.4052; tert-Bu, iso-Pr, -, 80°/11, 1.4035; Am, Am, -, 120°/11, 1.4121; n-C8H17, Et, -, 150°/11, 1.4146; n-C8H17, n-C8H17, -, 130°/0.05, 1.4305; n-C18H37, Me, 31-3°, 160°/0.001, -; cyclohexyl, cyclohexyl, sublimes 210°, 120°/0.05, -; PhCH2, PhCH2, -, 125°/0.05, 1.5278; (R1R2N =) Δ3-pyrrolyl, -, 90°/11, 1.4195; (R1R2N =) pyrrolidinyl, -, 90°/11, 1.4082; (R1R2N =) 2-methylpyrrolidinyl, -, 100°/11, -; (R1R2N =) 3-methylpyrrolidinyl, -, 100°/11, 1.4094; (R1R2N =) 2-ethylpyrrolidinyl, -, 105°/11, 1.4141; (R1R2N =) 2-propylpyrrolidinyl, -, 110°/11, 1.4188; (R1R2N =) 2-phenylpyrrolidinyl, -, 115°/0.05, 1.4911; (R1R2N =) 2-pyrridylpyrrolidinyl, -, 125°/0.05, 1.4962; (R1R2N =) 2,3-dimethylpyrrolidinyl, -, 100°/11, 1.4129; (R1R2N =) 2,4-dimethylpyrrolidinyl, -, 95°/11, 1.4080; (R1R2N =) 2,5-dimethylpyrrolidinyl, -, 90°/11, 1.4116; (R1R2N =) 3,4-dimethylpyrrolidinyl, -, 130°/11, -; (R1R2N =) piperidino, -, 90°/11, 1.4170; (R1R2N =) 2-methylpiperidino, -, 105°/11, 1.4205; (R1R2N =) 3-methylpiperidino, -, 100°/11, 1.4175; (R1R2N =) 4-methylpiperidino, -, 105°/11, 1.4181; (R1R2N =) 2-ethylpiperidino, -, 110°/11, 1.4246; (R1R2N =) 2,3-dimethylpiperidino, -, 115°/11, 1.4246; (R1R2N =) 2,4-dimethylpiperidino, -, 110°/11, 1.4201; (R1R2N =) 2,6-dimethylpiperidino, -, 110°/11, 1.4262; (R1R2N =) morpholino, -, 115°/11, 1.4182; Ph, H, 89-90°, 50°/0.001, -; 2-MeC6H4, H, 78-9°, 60°/0.001, -; 3-MeC6H4, H, 64.5-5.5°, 70°/0.001, -; 4-MeC6H4, H, 111°, 70°/0.001, -; 2-EtC6H4, H, 92-3°, 80°/0.001, -; 4-EtC6H4, H, 103-4°, 80°/0.001, -; 2,3-Me2C6H3, H, 97°, 80°/0.001, -; 2,4-Me2C6H3, H, 91°, 75°/0.001, -; 2,5-Me2C6H3, H, 84-6°, 75°/0.001, -; 2,6-Me2C6H3, H, 89-90°, 80°/0.001, -; 3,4-Me2C6H3, H, 73°, 80°/0.001, -; 3,5-Me2C6H3, H, 83-5°, 80°/0.001, -; 2,4,6-Me3C6H2, H, 139-40°, 90°/0.001, -; 2-HOC6H4, H, sublimes 167-9°, 110°/0.001, -; 3-HOC6H4, H, 131-2°, 115°/0.001, -; 4-HOC6H4, H, 172-3°, 120°/0.001, -; 2-MeOC6H4, H, 50-50.5°, 90°/0.001, -; 3-MeOC6H4, H, 75°, 105°/0.001, -; 4-MeOC6H4, H, 112°, 105°/0.001, -; 2-EtOC6H4, H, 141-2°, 110°/0.001, -; 1-C10H7, H, 102-3°, 100°/0.001, -; 2-C10H7, H, 146-7.5°, 120°/0.001, -; 2-fluorenyl, H, 201-2°, 160°/0.001, -; 9-fluorenyl, H, sublimes, 160°/0.001, -; 4-stilbenyl, H, 213-14°, 180°/0.001, -; azobenzene, H, 178-9°, 120°/0.001, -; 1-(2-HOC10H6), H, 168-9.5°, 140°/0.001, -; 2-PhC6H4, H, 99-101°, 100°/0.001, -; 4-PhC6H4, H, 200°, 190°/0.001, -; 2-pyridyl, H, 75-7°, 75°/0.001, -; 3-pyridyl, H, 127-8°, 110°/0.001, -; 5-isoquinolyl, H, 202-4°, 155°/0.001, -; 8-isoquinolyl, H, 215°, 140°/0.001, -; Ph, Me, 26-7°, 120°/11, 1.4681; Ph, Et, -, 120°/11, 1.4680; Ph, iso-Pr, 88-9°, 80°/0.001, -; PhCH2, Ph, 88-9°, 80°/0.001, -; 2-MeC6H4, Me, -, 125°/11, 1.4729; 2-MeC6H4, Et, -, 130°/11, 1.4731; 1-C10H7, Ph, 97-9°, 130°/0.001, -; 2-C10H7, Ph, 75-7°, 140°/0.001, -; Ph, Ph, 71-2°; 100°/0.001, -. Following (F3CCONH)2R were also prepared (R, m.p., and b.p./mm. given): CH2CH2, 204-6°, 140°/0.001; (CH2)3, 116-17°, 110°/0.005; (CH2)4, 155-7°, 120°/0.002; (CH2)5, 110-12°, 140°/0.002; (CH2)6, 121-3°, 150°/0.002; 1,2-C6H4, 158-8.5°, 130°/0.002; 1,3-C6H4, sublimes 225-8°, 140°/0.002; 1,4-C6H4, 249-50°, 160°/0.01; 4-methyl-1,2-phenylene, sublimes 197-9°, 150°/0.002; 4-methyl-1,3-phenylene, 183-4°, 160°/0.002; 5-methyl-1,4-phenylene, 190.5-1.5°, 150°/0.008; 2,2′-C6H4C6H4, 161-2°, 160°/0.001; 2,2′-C6H4CH:CHC6H4, sublimes 270°, 195°/0.01, -. Following CF3CF2CONHR were prepared (R, m.p., and b.p./0.001 mm. given): Ph, 98-9°, 65°; 2-MeC6H4, 78-9°, 65°; 3-MeC6H4, 52-3°, 70°; 4-MeC6H4, 111-12°, 75°; 2-EtC6H4, 64-5°, 70°; 4-EtC6H4, 121-2°, 80°; 2,3-Me2C6H3, 89-90°, 80°; 2,4-Me2C6H3, 55-7°, 75°; 2,5-Me2C6H3, 101-2°, 80°; 2,6-Me2C6H3, 108-9°, 80°; 3,4-Me2C6H3, 82-3°, 80°; 3,5-Me2C6H3, 94-5°, 80°; 2,4,6-Me3C6H2, 90-1°, 90°. Also prepared were: 2-trifluoroacetylpyrrole, m. 48.5°, 1,4-bis(trifluoroacetyl)piperazine, m. 111.5-12.5°, and 3-trifluoroacetylinodle m. 215-16°.

Monatshefte fuer Chemie published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, COA of Formula: C6H10F3NO.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Uhlemann, Erhard published the artcileSynthesis of 1,1-disubstituted 3-thiobenzoylthioureas, COA of Formula: C5H10N2OS, the publication is Zeitschrift fuer Chemie (1981), 21(11), 413-14, database is CAplus.

The title thioureas were prepared by acylation of PhCSNH₂ with dialkyl(thio)carbamoyl chlorides in pyridine in the presence of Ni(OAc)₂ (isolated as the Ni chelates), thiobenzoylation of thioureas with PhCS₂CH₂CO₂H in MeCN containing KOH, or treating dialkyl(thio)carbamoyl isothiocyanates with PhMgBr in Et₂O.

Zeitschrift fuer Chemie published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C8H8ClN5, COA of Formula: C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics