Author: Jessica.F

Fier, Patrick S. published the artcileSelective C-H Fluorination of Pyridines and Diazines Inspired by a Classic Amination Reaction, Name: N,N-Diethylisonicotinamide, the publication is Science (Washington, DC, United States) (2013), 342(6161), 956-960, database is CAplus and MEDLINE.

Fluorinated heterocycles are prevalent in pharmaceuticals, agrochems., and materials. However, reactions that incorporate fluorine into heteroarenes are limited in scope and can be hazardous. The authors present a broadly applicable and safe method for the site-selective fluorination of a single carbon-hydrogen bond in pyridines and diazines using com. available silver(II) fluoride. The reactions occur at ambient temperature within 1 h with exclusive selectivity for fluorination adjacent to nitrogen. The mild conditions allow access to fluorinated derivatives of medicinally important compounds, as well as a range of 2-substituted pyridines prepared by subsequent nucleophilic displacement of fluoride. Mechanistic studies demonstrate that the pathway of a classic pyridine amination can be adapted for selective fluorination of a broad range of nitrogen heterocycles.

Science (Washington, DC, United States) published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C10H14N2O, Name: N,N-Diethylisonicotinamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Mokry, Cornelia published the artcilePreparation and properties of 2-(dialkylamino)-5-(haloacetyl)thiazoles and 4-[2-(dialkylamino)-5-thiazolyl]thiazoles, Application In Synthesis of 14294-10-1, the publication is Journal fuer Praktische Chemie/Chemiker-Zeitung (1998), 340(4), 375-380, database is CAplus.

By the reaction of N-acylthioureas with (ClCH₂)₂CO, 2-(dialkylamino)-5-(chloroacetyl)thiazoles are available. These compounds react with thioureas or arylthioamides under heterocyclization to give bis[2-(dialkylamino)-5-thiazolyl]methanones, 2-aryl-4-[2-(dialkylamino)-5-thiazolyl]thiazoles, or 2-(dialkylamino)-4-[2-(dialkylamino)-5-thiazolyl]thiazoles, resp., from which the latter exhibit a high reactivity towards several electrophilic reagents. Thus, deeply colored cyanovinyl-, arylazo-, and arylmethine-substituted bisthiazole dyes formed.

Journal fuer Praktische Chemie/Chemiker-Zeitung published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Application In Synthesis of 14294-10-1.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Liebscher, Juergen published the artcileNitrile-formamide chloride adducts; VII. A simple route to 6-N-formamidino-1,3-thiazinium salts, SDS of cas: 14294-10-1, the publication is Zeitschrift fuer Chemie (1976), 16(7), 268-70, database is CAplus.

R3R4N+:CHCR:CClN:CHNR1R2 ClO4-(I; R = Ph, CN, CO2Et, 4-ClC6H4, etc; R1, R2, R3, R4 = Me; R1R2N, R3R4N = morpholino) reacted with R5CSNH2 (R5 = Ph, Me2N, morpholino, PhNH, etc.) to give the thiazinium salts II. I were prepared by the reaction of RCH2CN with dialkylformamide chlorides in the presence of HCl.

Zeitschrift fuer Chemie published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, SDS of cas: 14294-10-1.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Liebscher, Juergen published the artcileNitrile-formamide adducts. 4. Reaction of nitrile-formamide adducts. Synthesis of N-thioacylamide derivatives and aza analogs of thiopyrylium salts, Safety of Morpholine-4-carbothioamide, the publication is Zeitschrift fuer Chemie (1975), 15(11), 438-40, database is CAplus.

4-RC6H4CSN:CHNR1R2 (R = H, Me, OMe; NR1R2 = pyrrolidino, morpholino, NMe2) were obtained by treating 4-RC6H4CONHCH:N+R1R2 ClO4- with P2S5 or by treating 4-RC6H4CCl:NCH:N+R1R2 ClO4- (I) with Na2S or Na2S2O3. 4-RC6H4CSN:CHNR1R2 were hydrolyzed to 4-RC6H4CSNHCHO or condensed with I (R = H, Cl) to the thiazines II. The thiadiazines III were similarly obtained from I and R4NHCSNR1R2 (R4 = Bz, 4-O2NC6H4CO, 3-O2NC6H4CO, H).

Zeitschrift fuer Chemie published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Safety of Morpholine-4-carbothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Liebscher, Juergen published the artcileReaction of 3-chloroprop-2-eniminium salts with alkali rhodanides, SDS of cas: 14294-10-1, the publication is Zeitschrift fuer Chemie (1978), 18(9), 334-5, database is CAplus.

The pyrimidinethiones I (R = Ph, 4-MeC₆H₄, 4-MeOC₆H₄, 4-ClC₆H₄, 2-naphthyl; R¹ = 4-MeOC₆H₄, 2-MeOC₆H₄, 4-MeC₆H₄, 2-naphthyl, 3-MeOC₆H₄) were obtained by treating RCCl:CHCH:N⁺Me₂ ClO₄^– was alkali metal isothiocyanate and treating SCNCR:CHCH:N⁺Me₂ ClO₄^– (II) with R¹NH₂. Treatment of II with R₂²NH (NR₂² = morpholino, pyrrolidino, NMe₂) gave the thiazinium salts III (R³ = H). Reaction of III (R = 4-MeC₆H₄, NR₂² = NMe₂, R³ = H) with PhNMe₂ gave III (R = 4-MeC₆H₄, NR₂² = NMe₂, R³ = 4-Me₂NC₆H₄).

Zeitschrift fuer Chemie published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, SDS of cas: 14294-10-1.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Keil, Dietmar published the artcileA simple route to N,N-disubstituted selenoureas from N,N-disubstituted cyanamides, Application In Synthesis of 2451-91-4, the publication is Synthesis (2004), 15-16, database is CAplus.

N,N-Disubstituted selenoureas I [R¹ = R² = Me, Et, Bn; R¹R² = O(CH₂CH₂)₂, (CH₂)₅, (CH₂)₄] can be obtained in good yields by addition of an acid to a mixture of freshly prepared sodium selenide and N,N-disubstituted cyanamides II.

Synthesis published new progress about 2451-91-4. 2451-91-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Benzene, name is N,N-Dibenzylcyanamide, and the molecular formula is C15H14N2, Application In Synthesis of 2451-91-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Keil, Dietmar published the artcilePreparation and characterization of N,N-disubstituted 2-amino-selenazoles, Recommanded Product: N,N-Dibenzylcyanamide, the publication is Phosphorus, Sulfur and Silicon and the Related Elements (1999), 169-184, database is CAplus.

As a result of checking suited methods for preparing N,N-disubstituted 2-amino-selenazoles, e.g. I, as a nearly unknown class of highly reactive selenazoles a simple route starting from N,N-disubstituted selenoureas has been elaborated and used for the synthesis of a series of these compounds The necessary selenium-containing starting compounds N,N-disubstituted selenoureas are available from N,N-disubstituted cyanamides and hydrogen selenide.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about 2451-91-4. 2451-91-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Benzene, name is N,N-Dibenzylcyanamide, and the molecular formula is C15H14N2, Recommanded Product: N,N-Dibenzylcyanamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Flaig, Ronald published the artcileSynthesis of N-substituted 2,4-diaminothiazoles and their salts, Product Details of C5H10N2OS, the publication is Heterocycles (1997), 45(5), 875-888, database is CAplus.

A series of N(2),N(4)-substituted 2,4-diaminothiazoles I (R¹R²N = morpholino, pyrrolidino, piperidino, diethylamino, n-butylamino, phenylamino, di-n-propylamino, R³R⁴N = morpholino, pyrrolidino, piperidino, diphenylamino, diethylamino, n-butylamio) and their corresponding mineral acid salts have been prepared by the reaction of POCl₃ with N-substituted S-(dialkylaminocarbonylmethylene)isothiouronium salts R¹R²NC(:NH₂)SCH₂CONR³R⁴ available from corresponding substituted thioureas R¹R²NC(S)NH₂ (II) and N,N-disubstituted chloroacetamides ClCH₂CONR³R⁴ or by the reaction of primary or secondary amines R³R⁴NH in excess with N(2)-unsubstituted or N(2)-disubstituted 2-amino-4-thiazolinimine hydrochlorides III available by the reaction of corresponding N-substituted thioureas II with chloroacetonitrile.

Heterocycles published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Product Details of C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Czerney, Peter published the artcileHeterocyclic substituted coumarins from β-chloropropeniminium salts, Application of Morpholine-4-carbothioamide, the publication is Journal fuer Praktische Chemie (Leipzig) (1982), 324(2), 255-66, database is CAplus.

The chloropropeniminium salts I (X = N⁺Me₂ ClO₄^–; R = H, 6-Br, 7-OH, 7-OMe, 7-NMe₂, 7-pyrrolidino, 8-OMe, 7-NEt₂, R¹ = H; RR¹ = 5,6-CH:CHCH:CH, 7,8-CH:CHCH:CH) and the aldehydes I (X = O) were prepared by treating 3-acetylcoumarins with DMF-POCl₃ in the presence of HClO₄ or H₂O, resp. I are versatile synthetic intermediates giving I (X = CR²CN, R² = cyano, CO₂Et, 2-benzimidazolyl, 4-O₂NC₆H₄) which were converted to the aminobutadienes. I were also cyclized to pyrylium, thiopyrylium, pyrazolyl, and thiazinyl derivatives

Journal fuer Praktische Chemie (Leipzig) published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Application of Morpholine-4-carbothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Keil, D. published the artcileSynthesis and characterization of 1,3-bis-(2-dialkylamino-5-thiazolyl)-substituted squaraines and their 2-(dialkylamino)thiazole precursors, Product Details of C5H10N2OS, the publication is Liebigs Annalen (1995), 979-84, database is CAplus.

By condensing of squaric acid with 2-(dialkylamino)-substituted thiazoles, a novel type of heterocyclic-substituted squaraines was prepared in moderate yield mostly. The squaraines are sparingly soluble in most organic solvents and exhibit narrow absorption bands in the visible range at ∼ 620-700 nm in solution. In dispersed form, the absorption bands of the squaraines are, however, broadened and shifted into the near IR region at ∼ 900 nm. These unique properties of the new squaraines suggest the use of these dyes as spectral sensitizers for laser-driven data recording or data storage media.

Liebigs Annalen published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Product Details of C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics